Infections of humans with Marburg and Ebola viruses cause similar syndromes, with severe hemorrhages, vomiting, abdominal pain, myalgia, pharyngitis, conjunctivitis, and proteinuria. The onset is sudden, and progress to prostration, profound hypotension, and death is rapid. The mortality rate in the known outbreaks has been very high; 25% with Marburg virus, and 60% in the Sudan outbreak and 90% in the Zaire outbreak of Ebola virus infection. However, although several infections of laboratory workers and animal handlers with the Reston virus were recognized serologically, they were not associated with human disease.
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