Clinical Features

The disease begins after a very short incubation period (2-6 days) with fever, severe headache, retroorbital pain, photophobia, and generalized myalgia. In the Egyptian epidemic a proportion of the patients progressed to one of three complications: encephalitis (relatively mild and usually without sequelae), retinitis (with diminution of visual acuity sometimes leading to permanent loss of central vision), or hemorrhagic fever (marked by jaundice and widespread hemorrhage, with a mortality of 5-10%).

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