To cause infection, virus particles must be able to hind to cells. IJgands on specilic molecules on the surface of the virion (viral allarliment po/ems) bind to receptors on the plasma membrane of the cell (Table 3-2) For instance, X-ray crystallography reveals that the receptor for most orthomyxoviruses is the terminal sialic acid on an oligosaccharide side chain of a cellular glycoprotein (ot glycohpid), while the Iigand is in a cleft at the distal tip of each monomer of e c ni — c Sí BD O


Was this article helpful?

0 0

Post a comment