TCell Vaccination Is a Possible Therapy

The Revised Authoritative Guide To Vaccine Legal Exemptions

Vaccines Have Serious Side Effects

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The basis for T-cell vaccination as a therapy for some autoimmune diseases came from experiments with the EAE animal model. When rats were injected with low doses (<10-4) of cloned T cells specific for MBP, they did not develop

FIGURE 20-10

Autoreactive T cell

Anti-

Anti-

MHC

TCR

Autoreactive T cell

FIGURE 20-10

Some experimental agents for immunointervention in autoimmune disease.

symptoms of EAE. Instead they became resistant to the development of EAE when later challenged with a lethal dose of activated MBP-specific T cells or MBP in adjuvant. Later findings revealed that the efficacy of these autoimmune T-cell clones as a vaccine could be enhanced by crosslinking the cell-membrane components with formaldehyde or glu-taraldehyde. When crosslinked T cells were injected into animals with active EAE, permanent remission of symptoms was observed. The crosslinked T cells apparently elicit regulatory T cells specific for TCR variable-region determinants of the autoimmune clones. Presumably these regulatory T cells act to suppress the autoimmune T cells that mediate EAE.

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Essentials of Human Physiology

Essentials of Human Physiology

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