References

Abbas, A., K. M. Murphy, and A. Sher. 1996. Functional diversity of helper T lymphocytes. Nature 383:787.

Alcami, A., and U. H. Koszinowski. 2000. Viral mechanisms of immune evasion. Immunol. Today 9:447-455.

Bach, E. A., M. Aguet, and R. D. Schreiber. 1998. The IFN-7 receptor: a paradigm for cytokine receptor signaling. Ann. Rev. Immunol. 15:563.

Darnell, J. E. Jr. 1997. STATs and gene regulation. Science 5332:1630-1635.

Go to www.whfreeman.com/immunology Self-Test

Review and quiz of key terms

Self-renewing hematopoietic stem cell

Self-renewing hematopoietic stem cell

SCF, others

SCF, others

Common myeloid progenitor

SCF, others

Common myeloid progenitor

Thrombpoietin, IL-11

Erythroid progenitor

Basophil progenitor

Erythroid progenitor m

Megakaryocyte

Basophil progenitor

Erythro-poietin cP

Erythrocyte

Basophil

Common lymphoid progenitor

Common lymphoid progenitor

Eosinophil progenitor

Eosinophil progenitor

IL-5

Basophil

IL-5

Eosinophil

Natural killer cell

IL-7, others

IL-7, others

Natural killer cell

IL-7, others

IL-7, others

B lymphocytes

Granulocyte-monocyte progenitor

Granulocyte-monocyte progenitor

G-CSF

G-CSF

Neutrophil

M-CSF

M-CSF

Monocyte

Eosinophil

Neutrophil

Monocyte

FIGURE 12-16

Hematopoietic cytokines and hematopoiesis. A variety of cytokines are involved in supporting the growth and directing the differentiation of hematopoietic cells. Note that additional factors may be required for some of the developmental pathways shown in the diagram. CFU = colony-forming unit, a cell capable of generating a colony of cells from which the fully differentiated cell type emerges.

Fitzgerald, K. A., et al. 2001. The Cytokine Facts Book, second edition. Academic Press.

Flynn, J. L., and J. Chan. 2001. Immunology of tuberculosis. Annu. Rev. Immunol. 19:93-129.

Gadina, M., et al. 2001. Signaling by type I and II cytokine receptors: ten years after. Curr. Opin. Immunol. 3:363-373.

Jaeckel, E., et al. 2001. Treatment of acute hepatitis C with interferon a-2b. N. Engl. J .Med. 345:1452-1457.

Mossman, T. R., H. Cherwinski, M. W. Bond, M. A. Gledlin, and R. L. Coffman. 1986. Two types of murine helper T cell clone.

I. Definition according to profiles of lymphokine activities and secreted proteins. J. Immunology 136:2348.

Rengarajan, J., S. J. Szabo, and L. H. Glimcher. 2000. Transcriptional regulation of ThH1/ThH2 polarization. Immunol. Today 10:479-483.

Szabo, S. J. et al. 2000. A novel transcription factor, T-bet, directs TH1 lineage commitment. Cell 100:655-669.

Walter, M. R., et al. 1995. Crystal structure of a complex between interferon-7 and its soluble high-affinity receptor. Nature 376: 230.

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