Opsonization Is Promoted by Antibody

Opsonization, the promotion of phagocytosis of antigens by macrophages and neutrophils, is an important factor in antibacterial defenses. Protein molecules called Fc receptors (FcR), which can bind the constant region of Ig molecules, are present on the surfaces of macrophages and neutrophils.

The binding of phagocyte Fc receptors with several antibody molecules complexed with the same target, such as a bacterial cell, produces an interaction that results in the binding of the pathogen to the phagocyte membrane. This crosslinking of the FcR by binding to an array of antibody Fc regions initiates a signal-transduction pathway that results in the phagocytosis of the antigen-antibody complex. Inside the phagocyte, the pathogen becomes the target of various destructive processes that include enzymatic digestion, oxidative damage, and the membrane-disrupting effects of antibacterial peptides.

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Essentials of Human Physiology

Essentials of Human Physiology

This ebook provides an introductory explanation of the workings of the human body, with an effort to draw connections between the body systems and explain their interdependencies. A framework for the book is homeostasis and how the body maintains balance within each system. This is intended as a first introduction to physiology for a college-level course.

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