Multigene Organization of Ig Genes

As cloning and sequencing of the light- and heavy-chain DNA was accomplished, even greater complexity was revealed than had been predicted by Dreyer and Bennett. The k and X light chains and the heavy chains are encoded by separate multigene families situated on different chromosomes (Table 5-1). In germ-line DNA, each of these multigene families contains several coding sequences, called gene segments, separated by noncoding regions. During B-cell maturation, these gene segments are rearranged and brought together to form functional immunoglobulin genes.

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Essentials of Human Physiology

Essentials of Human Physiology

This ebook provides an introductory explanation of the workings of the human body, with an effort to draw connections between the body systems and explain their interdependencies. A framework for the book is homeostasis and how the body maintains balance within each system. This is intended as a first introduction to physiology for a college-level course.

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