As cloning and sequencing of the light- and heavy-chain DNA was accomplished, even greater complexity was revealed than had been predicted by Dreyer and Bennett. The k and X light chains and the heavy chains are encoded by separate multigene families situated on different chromosomes (Table 5-1). In germ-line DNA, each of these multigene families contains several coding sequences, called gene segments, separated by noncoding regions. During B-cell maturation, these gene segments are rearranged and brought together to form functional immunoglobulin genes.
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This ebook provides an introductory explanation of the workings of the human body, with an effort to draw connections between the body systems and explain their interdependencies. A framework for the book is homeostasis and how the body maintains balance within each system. This is intended as a first introduction to physiology for a college-level course.