Lymphocyte Recirculation

Lymphocytes are capable of a remarkable level of recirculation, continually moving through the blood and lymph to the various lymphoid organs (Figure 15-1). After a brief transit time of approximately 30 min in the bloodstream, nearly 45% of all lymphocytes are carried from the blood directly to the spleen, where they reside for approximately 5 h. Almost equal numbers (42%) of lymphocytes exit from the blood into various peripheral lymph nodes, where they reside for about 12 h. A smaller number of lymphocytes (10%) migrate to tertiary extralymphoid tissues by crossing between endothelial cells that line the capillaries. These tissues normally have few, if any, lymphoid cells but can import them during an inflammatory response. The most immuno-logically active tertiary extralymphoid tissues are those that interface with the external environment, such as the skin and various mucosal epithelia of the gastrointestinal, pulmonary, and genitourinary tracts.

The process of continual lymphocyte recirculation allows maximal numbers of antigenically committed lymphocytes to encounter antigen. An individual lymphocyte may make a complete circuit from the blood to the tissues and lymph

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Essentials of Human Physiology

Essentials of Human Physiology

This ebook provides an introductory explanation of the workings of the human body, with an effort to draw connections between the body systems and explain their interdependencies. A framework for the book is homeostasis and how the body maintains balance within each system. This is intended as a first introduction to physiology for a college-level course.

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