Immunoglobulin G IgG

IgG, the most abundant class in serum, constitutes about 80% of the total serum immunoglobulin. The IgG molecule consists of two 7 heavy chains and two k or two X light chains (see Figure 4-13a). There are four human IgG subclasses, distinguished by differences in 7-chain sequence and numbered according to their decreasing average serum concentrations: IgG1, IgG2, IgG3, and IgG4 (see Table 4-2).

The amino acid sequences that distinguish the four IgG subclasses are encoded by different germ-line CH genes, whose DNA sequences are 90%-95% homologous. The structural characteristics that distinguish these subclasses from one another are the size of the hinge region and the number and position of the interchain disulfide bonds between the heavy chains (Figure 4-14, page 92). The subtle

CLINICAL FOCUS

CLINICAL FOCUS

Passive Antibody Therapy

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Essentials of Human Physiology

Essentials of Human Physiology

This ebook provides an introductory explanation of the workings of the human body, with an effort to draw connections between the body systems and explain their interdependencies. A framework for the book is homeostasis and how the body maintains balance within each system. This is intended as a first introduction to physiology for a college-level course.

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