IgD was first discovered when a patient developed a multiple myeloma whose myeloma protein failed to react with anti-isotype antisera against the then-known isotypes: IgA, IgM, and IgG. When rabbits were immunized with this myeloma protein, the resulting antisera were used to identify the same class of antibody at low levels in normal human serum. The new class, called IgD, has a serum concentration of 30 ^g/ml and constitutes about 0.2% of the total immunoglobulin in serum. IgD, together with IgM, is the major membrane-bound immunoglobulin expressed by mature B cells, and its role in the physiology of B cells is under investigation. No biological effector function has been identified for IgD.
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This ebook provides an introductory explanation of the workings of the human body, with an effort to draw connections between the body systems and explain their interdependencies. A framework for the book is homeostasis and how the body maintains balance within each system. This is intended as a first introduction to physiology for a college-level course.