The class III region of the MHC in humans and mice contains a heterogeneous collection of genes (see Figure 7-15). These genes encode several complement components, two steroid 21-hydroxylases, two heat-shock proteins, and two cytokines (TNF-a and TNF-p). Some of these class III MHC gene products play a role in certain diseases. For example, mutations in the genes encoding 21-hydroxylase have been linked to congenital adrenal hyperplasia. Interestingly, the presence of a linked class III gene cluster is conserved in all species with an MHC region.
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This ebook provides an introductory explanation of the workings of the human body, with an effort to draw connections between the body systems and explain their interdependencies. A framework for the book is homeostasis and how the body maintains balance within each system. This is intended as a first introduction to physiology for a college-level course.