Human MHC Class III Genes Are Between Class I and II

The class III region of the MHC in humans and mice contains a heterogeneous collection of genes (see Figure 7-15). These genes encode several complement components, two steroid 21-hydroxylases, two heat-shock proteins, and two cytokines (TNF-a and TNF-p). Some of these class III MHC gene products play a role in certain diseases. For example, mutations in the genes encoding 21-hydroxylase have been linked to congenital adrenal hyperplasia. Interestingly, the presence of a linked class III gene cluster is conserved in all species with an MHC region.

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Essentials of Human Physiology

Essentials of Human Physiology

This ebook provides an introductory explanation of the workings of the human body, with an effort to draw connections between the body systems and explain their interdependencies. A framework for the book is homeostasis and how the body maintains balance within each system. This is intended as a first introduction to physiology for a college-level course.

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