The concept that the rejection of foreign tissue is the result of an immune response to cell-surface molecules, now called histocompatibility antigens, originated from the work of Peter Gorer in the mid-1930s. Gorer was using inbred strains of mice to identify blood-group antigens. In the course of these studies, he identified four groups of genes, designated I through IV, that encoded blood-cell antigens. Work carried out in the 1940s and 1950s by Gorer and George Snell established that antigens encoded by the genes in the group designated II took part in the rejection of transplanted tumors and other tissue. Snell called these genes "histocompatibility
Presentation of Vesicular Stomatitis Virus Peptide (top) and Sendai Virus Nucleoprotein Peptide by Mouse MHC Class I Molecule H-2Kb
■ General Organization and Inheritance of the MHC
■ MHC Molecules and Genes
■ Detailed Genomic Map of MHC Genes
■ Cellular Distribution of MHC Molecules
■ Regulation of MHC Expression
■ MHC and Immune Responsiveness
■ MHC and Disease Susceptibility genes"; their current designation as histocompatibility-2 (H-2) genes was in reference to Gorer's group II blood-group antigens. Although Gorer died before his contributions were recognized fully, Snell was awarded the Nobel prize in 1980 for this work.
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This ebook provides an introductory explanation of the workings of the human body, with an effort to draw connections between the body systems and explain their interdependencies. A framework for the book is homeostasis and how the body maintains balance within each system. This is intended as a first introduction to physiology for a college-level course.