Gd T Cells Are Far Less Pervasive Than ab T Cells

In humans, less than 5% of T cells bear the 78 heterodimer, and the percentage of 78 T cells in the lymphoid organs of mice has been reported to range from 1% to 3%. In addition to their presence in blood and lymphoid tissues, they also appear in the skin, intestinal epithelium, and pulmonary epithelium. Up to 1% of the epidermal cells in the skin of mice are 78 T cells. In general, 78 T cells are not MHC-restricted, and most do not express the coreceptors CD4 and CD8 present on populations of ap T cells. Although the potential of the 7 and 8 TCR loci to generate diversity is great, very little diversity is found in this type of T cell. In fact, as pointed out in Chapter 9, most of the 78 T cells in humans have an identical combination of 78 chains (79 and 82).

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Essentials of Human Physiology

Essentials of Human Physiology

This ebook provides an introductory explanation of the workings of the human body, with an effort to draw connections between the body systems and explain their interdependencies. A framework for the book is homeostasis and how the body maintains balance within each system. This is intended as a first introduction to physiology for a college-level course.

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