By the early 1980s, investigators had learned much about T-cell function but were thwarted in their attempts to
ART TO COME
Interaction of aß TCR with Class II MHC-Peptide
■ Early Studies of the T-Cell Receptor
■ aß and y8 T-Cell Receptors: Structure and Roles
■ Organization and Rearrangement of TCR Genes
■ T-Cell Receptor Complex: TCR-CD3
■ T-Cell Accessory Membrane Molecules
■ Three-Dimensional Structures of TCR-Peptide-MHC Complexes
■ Alloreactivity of T Cells identify and isolate its antigen-binding receptor. The obvious parallels between the recognition functions of T cells and B cells stimulated a great deal of experimental effort to take advantage of the anticipated structural similarities between immunoglobulins and T-cell receptors. Reports published in the 1970s claimed discovery of immunoglob-ulin isotypes associated exclusively with T cells (IgT) and of antisera that recognize variable-region markers (idio-types) common to antibodies and T-cell receptors with similar specificity. These experiments could not be reproduced and were proven to be incorrect when it was demonstrated that the T-cell receptor and immunoglobulins do not have common recognition elements and are encoded by entirely separate gene families. As the following sections will show, a sequence of well-designed experiments using cutting-edge technology was required to correctly answer questions about the structure of the T-cell receptor, the genes that encode it, and the manner in which it recognizes antigen.
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This ebook provides an introductory explanation of the workings of the human body, with an effort to draw connections between the body systems and explain their interdependencies. A framework for the book is homeostasis and how the body maintains balance within each system. This is intended as a first introduction to physiology for a college-level course.