Early Studies of the TCell Receptor

By the early 1980s, investigators had learned much about T-cell function but were thwarted in their attempts to

ART TO COME

Interaction of aß TCR with Class II MHC-Peptide

■ Early Studies of the T-Cell Receptor

■ aß and y8 T-Cell Receptors: Structure and Roles

■ Organization and Rearrangement of TCR Genes

■ T-Cell Receptor Complex: TCR-CD3

■ T-Cell Accessory Membrane Molecules

■ Three-Dimensional Structures of TCR-Peptide-MHC Complexes

■ Alloreactivity of T Cells identify and isolate its antigen-binding receptor. The obvious parallels between the recognition functions of T cells and B cells stimulated a great deal of experimental effort to take advantage of the anticipated structural similarities between immunoglobulins and T-cell receptors. Reports published in the 1970s claimed discovery of immunoglob-ulin isotypes associated exclusively with T cells (IgT) and of antisera that recognize variable-region markers (idio-types) common to antibodies and T-cell receptors with similar specificity. These experiments could not be reproduced and were proven to be incorrect when it was demonstrated that the T-cell receptor and immunoglobulins do not have common recognition elements and are encoded by entirely separate gene families. As the following sections will show, a sequence of well-designed experiments using cutting-edge technology was required to correctly answer questions about the structure of the T-cell receptor, the genes that encode it, and the manner in which it recognizes antigen.

Was this article helpful?

0 0
Essentials of Human Physiology

Essentials of Human Physiology

This ebook provides an introductory explanation of the workings of the human body, with an effort to draw connections between the body systems and explain their interdependencies. A framework for the book is homeostasis and how the body maintains balance within each system. This is intended as a first introduction to physiology for a college-level course.

Get My Free Ebook


Post a comment