Detailed Genomic Map of MHC Genes

The MHC spans some 2000 kb of mouse DNA and some 4000 kb of human DNA. The recently completed human genome sequence shows this region to be densely packed

Mhc Class Heavy Chain Gene

MOUSE CHROMOSOME 17

Complex

Class

50kb

400kb

1500kb

Loci

Centromere

HUMAN CHROMOSOME 6

Complex

Class

1000kb

4000 kb

1000kb

2000kb

Loci

Centromere qSÎSq qqqqq ^¡^ ci Ü ÈÈS? Ü^Ü^S^ S^S^sas^S^sas^

ÜÜÜÜÜÜMÜÜÜMÜMMÜMW^ÜÜÜMÜMfflOQMÜMÜÜÜüm.

Qq<0

Gene

CYP21,CYP21P

G7a/b

* Now designated HFE

Encoded protein Complement components Steroid 21-hydroxylases Valyl-tRNA synthetase Heat-shock protein Proteasome-like submits Peptide-transporter submits Tumor necrosis factors a and fl

FIGURE 7-15

Detailed genomic map of the mouse and human MHC, including genes encoding classical and nonclassical MHC molecules. The class I MHC genes are colored red, MHC II genes are colored blue, and genes in MHC III are colored green. Classical class I genes are labeled in red, class II in blue, and the nonclassical MHC genes are labeled in black. The concept of classical and nonclassical does not apply to class III. The functions for certain proteins encoded by the nonclassical class I genes are known. In the mouse, there are nonclassical genes located downstream from Tla that are not shown.

with genes, most of which have known functions. Our current understanding of the genomic organization of mouse and human MHC genes is diagrammed in Figure 7-15.

Was this article helpful?

0 0
Essentials of Human Physiology

Essentials of Human Physiology

This ebook provides an introductory explanation of the workings of the human body, with an effort to draw connections between the body systems and explain their interdependencies. A framework for the book is homeostasis and how the body maintains balance within each system. This is intended as a first introduction to physiology for a college-level course.

Get My Free Ebook


Post a comment