The MHC spans some 2000 kb of mouse DNA and some 4000 kb of human DNA. The recently completed human genome sequence shows this region to be densely packed
MOUSE CHROMOSOME 17
HUMAN CHROMOSOME 6
Centromere qSÎSq qqqqq ^¡^ ci Ü ÈÈS? Ü^Ü^S^ S^S^sas^S^sas^
* Now designated HFE
Encoded protein Complement components Steroid 21-hydroxylases Valyl-tRNA synthetase Heat-shock protein Proteasome-like submits Peptide-transporter submits Tumor necrosis factors a and fl
Detailed genomic map of the mouse and human MHC, including genes encoding classical and nonclassical MHC molecules. The class I MHC genes are colored red, MHC II genes are colored blue, and genes in MHC III are colored green. Classical class I genes are labeled in red, class II in blue, and the nonclassical MHC genes are labeled in black. The concept of classical and nonclassical does not apply to class III. The functions for certain proteins encoded by the nonclassical class I genes are known. In the mouse, there are nonclassical genes located downstream from Tla that are not shown.
with genes, most of which have known functions. Our current understanding of the genomic organization of mouse and human MHC genes is diagrammed in Figure 7-15.
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