Chapter

Secreted Membrane Bound Antibody

IgM, the First Responder

■ Basic Structure of Antibodies

■ Obstacles to Antibody Sequencing

■ Immunoglobulin Fine Structure

■ Antibody-Mediated Effector Functions

■ Antibody Classes and Biological Activities

■ Antigenic Determinants on Immunoglobulins

■ The Immunoglobulin Superfamily

■ Monoclonal Antibodies

Antibodies are the antigen-binding proteins present on the B-cell membrane and secreted by plasma cells. Membrane-bound antibody confers antigenic specificity on B cells; antigen-specific proliferation of B-cell clones is elicted by the interaction of membrane antibody with antigen. Secreted antibodies circulate in the blood, where they serve as the effectors of humoral immunity by searching out and neutralizing antigens or marking them for elimination. All antibodies share structural features, bind to antigen, and participate in a limited number of effector functions.

The antibodies produced in response to a particular antigen are heterogeneous. Most antigens are complex and contain many different antigenic determinants, and the immune system usually responds by producing antibodies to several epitopes on the antigen. This response requires the recruitment of several clones of B cells. Their outputs are monoclonal antibodies, each of which specifically binds a single antigenic determinant. Together, these monoclonal antibodies make up the polyclonal and heterogeneous serum antibody response to an immunizing antigen.

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Essentials of Human Physiology

Essentials of Human Physiology

This ebook provides an introductory explanation of the workings of the human body, with an effort to draw connections between the body systems and explain their interdependencies. A framework for the book is homeostasis and how the body maintains balance within each system. This is intended as a first introduction to physiology for a college-level course.

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