Antigenic Determinants on Immunoglobulins

Since antibodies are glycoproteins, they can themselves function as potent immunogens to induce an antibody response. Such anti-Ig antibodies are powerful tools for the study of B-cell development and humoral immune responses. The antigenic determinants, or epitopes, on immunoglobulin molecules fall into three major categories: isotypic, allotypic, and idiotypic determinants, which are located in characteristic portions of the molecule (Figure 4-17).


Allergen cross-linkage of receptor-bound IgE on mast cells induces degranulation, causing release of substances (blue dots) that mediate allergic manifestations.

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Essentials of Human Physiology

Essentials of Human Physiology

This ebook provides an introductory explanation of the workings of the human body, with an effort to draw connections between the body systems and explain their interdependencies. A framework for the book is homeostasis and how the body maintains balance within each system. This is intended as a first introduction to physiology for a college-level course.

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