Because leukocyte extravasation is an integral part of the inflammatory response, one approach for reducing inflammation is to impede this process. Theoretically, one way to reduce leukocyte extravasation is to block the activity of various adhesion molecules with antibodies. In animal models, for example, antibodies to the integrin LFA-1 have been used to reduce neutrophil buildup in inflammatory tissue. Antibodies to ICAM-1 have also been used, with some success, in preventing the tissue necrosis associated with burns and in reducing the likelihood of kidney-graft rejection in animal models. The results with antibodies specific for these ad-hesins have been so encouraging that a combination of antibodies (anti-ICAM-1 and anti-LFA-1) was used in clinical trials on human kidney-transplant patients. A combination of two anti-adhesins had to be used because failure to block both LFA-1 and ICAM-1 results in rejection.
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This ebook provides an introductory explanation of the workings of the human body, with an effort to draw connections between the body systems and explain their interdependencies. A framework for the book is homeostasis and how the body maintains balance within each system. This is intended as a first introduction to physiology for a college-level course.