Antibodies Activate Complement

IgM and, in humans, most IgG subclasses can activate a collection of serum glycoproteins called the complement system. Complement includes a collection of proteins that can perforate cell membranes. An important byproduct of the complement activation pathway is a protein fragment called C3b, which binds nonspecifically to cell- and antigen-antibody complexes near the site at which complement was activated. Many cell types—for example, red blood cells and macrophages—have receptors for C3b and so bind cells or complexes to which C3b has adhered. Binding of adherent C3b by macrophages leads to phagocytosis of the cells or molecular complexes attached to C3b. Binding of antigen-antibody complexes by the C3b receptors of a red blood cell allows the erythrocyte to deliver the complexes to liver or spleen, where resident macrophages remove them without destroying the red cell. The collaboration between antibody and the complement system is important for the inactivation and removal of antigens and the killing of pathogens. The process of complement activation is described in detail in Chapter 13.

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Essentials of Human Physiology

Essentials of Human Physiology

This ebook provides an introductory explanation of the workings of the human body, with an effort to draw connections between the body systems and explain their interdependencies. A framework for the book is homeostasis and how the body maintains balance within each system. This is intended as a first introduction to physiology for a college-level course.

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