The liver regulates the amount of cholesterol in the blood. The liver secretes cholesterol in the bile (which is stored in the gallbladder), which enters the gut. Therefore, there is a lot of cholesterol in the gut from the food we eat and the cholesterol made in the liver and then secreted into the gut. The most effective way to lower cholesterol is by both lowering the cholesterol made in the liver using a statin, and lowering the absorption of cholesterol from the gut into the bloodstream with ezetimibe.
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