Management of Antimicrobials in Infectious Diseases: Impact of Antibiotic Resistance is designed to help clinicians who provide care for common infectious conditions. The book is intended as a resource for generalist physicians and midlevel practitioners as well as infectious disease specialists. Our goal is to delineate an understanding of commonly encountered infectious pathogens and outline rational approaches to the management of clinical entities encountered in both ambulatory and hospital-based practice.

The World Health Organization's recent 2000 Report on Infectious Diseases is focused on overcoming antimicrobial resistance and alerts us to the global importance of this issue. Optimal antimicrobial use is essential in this era of escalating antibiotic resistance, and an understanding of the appropriate use of antimicrobials, particularly in light of resistant pathogens, is necessary for clinicians engaged in frontline care.

Management of Antimicrobials in Infectious Diseases: Impact of Antibiotic Resistance was designed as a resource for the evidence-based antimicrobial treatment of infectious diseases encountered in both the hospital and outpatient settings. Special emphasis is placed on those aspects of treatment necessitated by the growing problem of antibiotic resistance.

Management of Antimicrobials in Infectious Diseases: Impact of Antibiotic Resistance opens with chapters focusing on the significant pathogens, followed by articles concentrating on their clinical management. This strategy was undertaken to provide the clinician with two different, yet complementary, ways of understanding and managing a clinical problem. In addition, in order to more fully explicate the message of appropriate use of antimicrobials, coverage is accorded to strategies for promoting such appropriate antimicrobial use and to future trends in both treatment and antimicrobial resistance.

It is our hope that Management of Antimicrobials in Infectious Disease will disseminate the practical knowledge every physician treating infectious diseases needs, both to improve the quality of medical care and to help address the rise of antimicrobial resistance.

Arch G. Mainous III, PhD Claire Pomeroy, md

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