Laser Dosimetry

The appropriate light dose for a specific PDT treatment is determined by the size, location, and type of tumor. The light dose requirements for Photofrin® using 630-nm excitation are as follows (Fisher et al., 1996; Dougherty et al., 1998):

• Radiant Exposure: 25-500J/cm2 for surface treatment; 100-400J/cm2 for interstitial applications

• Maximum Irradiance: 200mW/cm2 for surface treatment; 400mw/cm2 for interstitial applications

The power requirements are not expected to be less for the new generation of PDT photosensitizers, because the primary focus has been on increasing the wavelength of excitation to achieve deeper penetration.

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