Optical Tracking of Drug Cell Interactions

Fluorescent Intake Cell

Two-photon laser scanning microscopy can readily be used to monitor the cellular entry pattern of a drug, by coupling a two-photon fluorescent probe to the drug. In collaboration with Nobel Laureate Andrew Schally of Tulane Uni-veristy, our group used optical tracking of a fluorescently labeled chemother-apeutic agent to monitor its cellular uptake and to understand the mechanism of chemotherapy Wang et al., 1999 Krebs et al., 2000 . Chemotherapy is commonly used in the treatment of cancers....

Laser Tissue Contouring And Restructuring

The two specific applications discussed here are for the use of lasers in der-matologic and ophthalmologic procedures. The theory of selective photother-molysis, introduced by Anderson and Parrish in 1981, is the basis for much advancement in dermatological lasers Anderson and Parrish, 1983 . It allows for highly localized destruction of light absorbing targets in skin, with minimal damage to the surrounding tissue. To achieve selective photother- molysis, an appropriate wavelength, exposure...