Intestinal FABP and lipoprotein metabolism

Intestinal fatty acid binding protein (I-FABP or FABP2) is a cytosolic intracellular protein capable of binding free fatty acids and delivering them to membranes. A common SNP in the I-FABP gene has been found at exon 2, with a G to A substitution resulting in a p.Ala54AThr substitution (Baier et al., 1995). The frequency of the T allele has been evaluated as 0.29 in Pima Indians and 0.27 in European students. Subjects presenting the T allelic variant show higher fatty acid binding and transport as well as higher triglyceride secretion into plasma from the intestine. In addition, clinical traits associated with the T allelic variant are higher insulinaemia and insulin-resistance, higher fasting LDL cholesterol and apoB levels, higher BMI and fasting triglycerides (Hegele, 1998; Agren et al., 1998). Moreover, the LDL cholesterol and apoB-lowering effects of diets rich in high-soluble fibre were more pronounced in subjects with the T variant (Hegele et al., 1997). In addition, subjects homozygous for the T variant have been shown to display increased postprandial insulin (Baier et al., 1995) or triglyceride responses (Agren et al., 1998), although in another study (Pratley et al., 2000) no marked difference was evidenced for glucose, non-esterified fatty acids or triglycerides.

Supplements For Diabetics

Supplements For Diabetics

All you need is a proper diet of fresh fruits and vegetables and get plenty of exercise and you'll be fine. Ever heard those words from your doctor? If that's all heshe recommends then you're missing out an important ingredient for health that he's not telling you. Fact is that you can adhere to the strictest diet, watch everything you eat and get the exercise of amarathon runner and still come down with diabetic complications. Diet, exercise and standard drug treatments simply aren't enough to help keep your diabetes under control.

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