Intestinal FABP and lipoprotein metabolism

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Intestinal fatty acid binding protein (I-FABP or FABP2) is a cytosolic intracellular protein capable of binding free fatty acids and delivering them to membranes. A common SNP in the I-FABP gene has been found at exon 2, with a G to A substitution resulting in a p.Ala54AThr substitution (Baier et al., 1995). The frequency of the T allele has been evaluated as 0.29 in Pima Indians and 0.27 in European students. Subjects presenting the T allelic variant show higher fatty acid binding and transport as well as higher triglyceride secretion into plasma from the intestine. In addition, clinical traits associated with the T allelic variant are higher insulinaemia and insulin-resistance, higher fasting LDL cholesterol and apoB levels, higher BMI and fasting triglycerides (Hegele, 1998; Agren et al., 1998). Moreover, the LDL cholesterol and apoB-lowering effects of diets rich in high-soluble fibre were more pronounced in subjects with the T variant (Hegele et al., 1997). In addition, subjects homozygous for the T variant have been shown to display increased postprandial insulin (Baier et al., 1995) or triglyceride responses (Agren et al., 1998), although in another study (Pratley et al., 2000) no marked difference was evidenced for glucose, non-esterified fatty acids or triglycerides.

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Diabetes 2

Diabetes 2

Diabetes is a disease that affects the way your body uses food. Normally, your body converts sugars, starches and other foods into a form of sugar called glucose. Your body uses glucose for fuel. The cells receive the glucose through the bloodstream. They then use insulin a hormone made by the pancreas to absorb the glucose, convert it into energy, and either use it or store it for later use. Learn more...

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