Neural tissues

Neural tissue is easiest to recognize when it is arranged into neural tubes or fetal neural rosettes (Figure 13.5).

Condensation of fetal neural cells may be associated with formation of glia-rich neu-ropil, indicative of maturation of fetal into adult-like cells (Figure 13.6). Specialized

Figure 13.4 Teratoma containing striated muscle cells. These cells are immunohistochemically positive for desmin (brown).
Embryonic Neural TissueHuman Embryonic Stem Cells Teratoma
Figure 13.6 Immature teratoma composed of fetal neural tissue forming neural tubes or indistinct aggregates. The immature neural cells are surrounded by more differentiated neuropil that appears pink.
Immature Neural Tissue

neural axis-derived cells such as pigmented, melanin-containing retinal cells may be seen focally (Figure 13.2). Structures resembling the choroid plexus of the cerebral ventricles may be also seen (Figure 13.1). Foci composed of primitive lens-forming eye cells are also occasionally seen (Figure 13.3).

Some tumors are almost exclusively formed of neural tissue. Neural tubes in such tumors are often multilayered (Figure 13.7). Despite considerable proliferative activity these cells are often positive for neural markers (Figures 13.8 and 13.9).

Figure 13.8 Immature teratoma immunohistochemically stained with antibodies to neurofilaments. Brown immunoreactants are signs of neural differentiation.
Neuropil Immature Teratoma
Figure 13.9 Immature teratoma immunohistochemically stained with antibodies to neurofilaments. Individual differentiated neural cells appear brown.

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