Progestogens

Progestogens* (progestins; gestogens) are female sex hormones, concerned with preparing the uterus for pregnancy, and then maintaining the necessary conditions. There is only one naturally occurring progestational steroid and that is progesterone

(Figure 5.128), which is secreted by the corpus luteum following release of an ovum. Progesterone is also an intermediate in the biosynthesis of the corticosteroids, e.g. hydrocortisone and aldosterone (see page 263), and its derivation from cholesterol via pregnenolone has already been seen in the formation of cardioactive glycosides (see page 243).

progesterone

Characteristic features of progestogens:

• C21 pregnane skeleton

• A4-3-keto progesterone

Characteristic features of progestogens:

• C21 pregnane skeleton

Figure 5.128

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