Mevastatin and other Statins

Mevastatin Hydrolysed Form

Mevastatin formerly compactin Figure 3.83 is produced by cultures of Penicillium citrinum and P. brevicompactum, and was shown to be a reversible competitive inhibitor of HMG-CoA reductase, dramatically lowering sterol biosynthesis in mammalian cell cultures and animals, and reducing total and low density lipoprotein cholesterol levels see page 236 . Mevastatin in its ring-opened form Figure 3.84 mimics the half-reduced substrate mevaldate hemithioacetal during the two-stage reduction of...

Vitamin D

Photosynthesis Vitamin

Vitamin D3 colecalciferol, cholecalciferol is a sterol metabolite formed photochemically in animals from 7-dehydrocholesterol by the sun's irradiation of the skin Figure 5.106 . 7-Dehydrocholesterol is the immediate A5'7 diene precursor of cholesterol see page 234 , and a photochemical reaction allows ring opening to precholecalciferol. A thermal 1,7-hydrogen shift follows to give colecalciferol vitamin D3 . Vitamin D3 is also manufactured photosynthetically by the same route. Vitamin D2...

Semi Synthesis of Corticosteroids

Synthesis Betamethasone

The medicinal use of corticosteroids was stimulated by reports of the dramatic effects of cortisone on patients suffering from rheumatoid arthritis in the late 1940s and early 1950s. The cortisone employed was isolated from the adrenal glands of cattle, and later was produced semi-synthetically by a laborious process from deoxycholic acid see page 260 isolated from ox bile and necessitating over 30 chemical steps. Increased demand for cortisone and hydrocortisone cortisol it had been shown that...

Forskolin

In a screening programme of Indian medicinal plants, extracts from the roots of Coleus forskohlii Labiatae Lamiaceae were discovered to lower blood pressure and have cardioactive properties. This led to the isolation of the diterpene forskolin coleonol Figure 5.51 as the active principle in yields of about 0.1 . Forskolin has been shown to exert its effects by direct stimulation of adenylate cyclase, and has become a valuable pharmacological tool in the study of this enzyme and its functions....