Effect of Inulin Type Fructans on Lipid Parameters in Noninsulin Dependent Diabetic Niddm Subjects

1. Administration of oligofructose in a packed coffee drink or coffee jelly for 14 d to uncontrolled diabetics (8 men and 10 women) fed a diabetic diet (55% carbohydrates, 25% fat, and 20% proteins) reduced total (8%) and LDL cholesterol (10%), compared with a control group given sucrose in the same food vehicles. No effects on other serum lipids but a decrease in blood glucose concentrations were observed.42

2. In a study with the aim to test the effects of oligofructose (15 g/d added as powder in a low-fat yogurt for 3 weeks) in noninsulin-dependent diabetic (NIDDM) subjects (n = 9 men and 11 women), no effects on blood lipids, lipoproteins, or glucose were observed.43

3. In NIDDM subjects (n = 12) oligofructose (20 g/d in habitual diet) had no effect on total or lipoprotein-bound cholesterol, plasma TAGs, hepatic glucose production, or insulin resistance.44

Data with respect to effects of inulin-type fructans on blood lipids in humans appear to be inconsistent, with reports of both positive and negative outcomes obtained from recent well-designed, double-blind, randomized, placebo-controlled human studies.45 There appear to be no obvious differences in the sex and ages of the subjects, the dosages employed (average 13.9 ± 4.8, range 8-20 g/d), duration of treatment (average 4 ± 1.6 weeks, range 2-8 weeks), and basal levels (i.e., before the treatment started) of either cholesterol (average 4.8 ± 1, range 3.9, 6.46 mM) or TAGs (average 1.16 ± 0.4, range 0.72, 1.65 mM) in the blood, between negative and positive studies (Table 11.2, Table 11.3, and Table 11.4). However, positive outcomes

Diet Duration Subjects (Weeks)

Men and Habitual women 2 weeks (48.5 ± 7.3) N = 8/10

Men and women (586 ± 5.2) (62 ± 4.1) N = 9/11 Men and women

Habitual 3 weeks

Habitual 4 weeks

Inulin g/d

OFS 8 g/d (coffee drink, coffee jelly)

INU 15 g/d (powder to be added to yogurt)

OFS 20 g/d (powder to sweeten beverages)

Blood Blood

Cholesterol Triglycerides (Total) (TAGs)

242 mg/dl D 0.921

6.01 mM NS

5.15 mM NS

132 mg/dl NS2

2.44 mM NS

1.42 mM NS

Miscellaneous Refs

Uncontrolled diabetics Diabetic diet (55% CHO,3 25% fat, 20% proteins) Decreased blood glucose

No effect on HDL or LDL No effect on FFA4 No effect on glycemia

No effect on cholesterol in lipoproteins or in plasma glucose and insulin

Supplements For Diabetics

Supplements For Diabetics

All you need is a proper diet of fresh fruits and vegetables and get plenty of exercise and you'll be fine. Ever heard those words from your doctor? If that's all heshe recommends then you're missing out an important ingredient for health that he's not telling you. Fact is that you can adhere to the strictest diet, watch everything you eat and get the exercise of amarathon runner and still come down with diabetic complications. Diet, exercise and standard drug treatments simply aren't enough to help keep your diabetes under control.

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