Mast Cells And Basophils

Mast cells and basophils are responsible for the initiation of IgE-mediated hypersensitivity responses. Many fungal organisms produce allergens that result in allergic fungal diseases including rhinitis, fungal sinusitis, asthma, and allergic bronchopulmonary mycosis (ABPM). These diseases are associated with elevated serum and fungal specific IgE, and by implication, type-1 hypersensitivity (Horner et al. 1995; Bush et al. 2004; Khun and Swain 2003 Kurup 2000). Although it is presumed that IgE-mediated mast cell and basophil reactions are central to fungal allergy, the strict requirement for IgE-mediated reactions is still debated. There is even more limited information on the contribution of mast cells or basophils to host defense against fungal pathogens, though there is the potential to regulate immune responses. Overall, in the host response to fungi, mast cells and basophils make versatile contributions to allergy, inflammation and host defense (Figure 1).

Mast Cells Fungi

Figure 1. The diverse role of mast cells and basophils in the regulation of host defense, allergy and innate responses. From Gali et al. 2001. "Analyzing the Roles of Mast cells and Basophils in Host Defense and Other Biological Responses". This figure is reprinted by courtesy of International Journal of Hematology."

Figure 1. The diverse role of mast cells and basophils in the regulation of host defense, allergy and innate responses. From Gali et al. 2001. "Analyzing the Roles of Mast cells and Basophils in Host Defense and Other Biological Responses". This figure is reprinted by courtesy of International Journal of Hematology."

Was this article helpful?

0 0
Allergic To Everything

Allergic To Everything

The human body And Todays chemical infested world. Here is a news flash You are not allergic to pollen, pet dander, or whatever it is that makes your body revolt Rather, your body just can not handle that one thing, what ever it is, anymore, due to the massive barrage of toxic chemicals you and everyone else are ingesting every single day.

Get My Free Audio and Ebook


Post a comment