Mast Cells And Basophils

Mast cells and basophils are responsible for the initiation of IgE-mediated hypersensitivity responses. Many fungal organisms produce allergens that result in allergic fungal diseases including rhinitis, fungal sinusitis, asthma, and allergic bronchopulmonary mycosis (ABPM). These diseases are associated with elevated serum and fungal specific IgE, and by implication, type-1 hypersensitivity (Horner et al. 1995; Bush et al. 2004; Khun and Swain 2003 Kurup 2000). Although it is presumed that IgE-mediated mast cell and basophil reactions are central to fungal allergy, the strict requirement for IgE-mediated reactions is still debated. There is even more limited information on the contribution of mast cells or basophils to host defense against fungal pathogens, though there is the potential to regulate immune responses. Overall, in the host response to fungi, mast cells and basophils make versatile contributions to allergy, inflammation and host defense (Figure 1).

Mast Cells Fungi

Figure 1. The diverse role of mast cells and basophils in the regulation of host defense, allergy and innate responses. From Gali et al. 2001. "Analyzing the Roles of Mast cells and Basophils in Host Defense and Other Biological Responses". This figure is reprinted by courtesy of International Journal of Hematology."

Figure 1. The diverse role of mast cells and basophils in the regulation of host defense, allergy and innate responses. From Gali et al. 2001. "Analyzing the Roles of Mast cells and Basophils in Host Defense and Other Biological Responses". This figure is reprinted by courtesy of International Journal of Hematology."

Was this article helpful?

0 0
51 Ways to Reduce Allergies

51 Ways to Reduce Allergies

Do you hate the spring? Do you run at the site of a dog or cat? Do you carry around tissues wherever you go? Youre not alone. 51 Ways to Reduce Allergies can help. Find all these tips and more Start putting those tissues away. Get Your Copy Of 51 Ways to Reduce Allergies Today.

Get My Free Ebook


Post a comment