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Hours post insult

Days post insult

Figure 2. (A) The time course of total cell infiltration in the acute response to Aspergillus fumigatus occurring in the allergic airway. (B) Each leukocyte and macrophage population typically follows a distinct time course of recruitment during the chronic allergic response (See Color Section.)

Allergic Response
Figure 3. An outline of the chronic responses occurring in the allergic airway following challenge with Aspergillus fumigatus, featuring a central role of macrophage activation and cytokine and chemokine production (See Color Section.)

Table 2. Manipulation of Cytokine & Chemokine Targets and their Effect Upon the Major Parameters of Fungal Asthma and ABPA Assessed in Mice

Mouse Antibody/ Prominent

Genotype Treatment Cytokine

Response

Serum Cellular AHR IgE Recruitment

Remodeling

Wild Type

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Coping with Asthma

Coping with Asthma

If you suffer with asthma, you will no doubt be familiar with the uncomfortable sensations as your bronchial tubes begin to narrow and your muscles around them start to tighten. A sticky mucus known as phlegm begins to produce and increase within your bronchial tubes and you begin to wheeze, cough and struggle to breathe.

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