Cryptococcus Neoformans

Cryptococcus neoformans is an encapsulated fungus that mainly causes infections of the central nervous system in immunocompromised individuals with T-cell defects (e.g., AIDS, lymphoproliferative disorders, immunosuppressive therapy), but which can also infect immunocompetent individuals (Dromer et al., 1996; Mitchell et al., 1995). The incidence of disseminated cryptococcosis has increased considerably in the last decades because of the AIDS pandemic, and still rises in developing areas such as Sub-Saharan Africa and Asia were highly active anti-retroviral therapy (HAART) and anti-fungal therapy are not readily available (Mwaba et al., 2001; Imwidthaya and Poungvarin, 2000; Hajjeh et al., 1999).

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