Thyroid Manifestations

Thyroid Factor

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Thyroid carcinoma occurs in 1-2% of FAP patients [138]. The relative risk of thyroid cancer has been estimated to be 7.6 (95% CL 2.5-17.7) in FAP [139] compared with the general population. FAP-associat-ed thyroid cancer is typically characterized by female predominance, young age at tumor diagnosis (usually 30 years or below), papillary differentiation, and multifocal involvement [140]. Therefore, several authors have advocated periodic thyroid evaluation in young women with FAP [139,140]. An association between FAP and thyroiditis has also been reported [141].

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