The Present Indications Efficacy Problems and Open Fields Using Infliximab in Crohns Disease

The first drug approved by the Food and Drug Administration for the treatment of CD was infliximab (Remicade) [5], a monoclonal chimeric antibody (human 75%, murine 25%). Infliximab neutralises biological activity of TNF-a by binding with high affinity to both soluble and transmembrane forms of TNF-a, inhibiting binding of TNF-a with its receptors. Therefore, infliximab heavy reduces TNF-a plasmatic levels and induces inflammatory cell apoptosis in the gut wall [6-9], thus promoting mucosal healing at colonoscopy [10,11].

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