Numerous factors have been studied to see if they can predict disease recurrence. In a retrospective analysis of 1 379 patients, Michalessi et al. identified the number of intestinal sites involved as an independent risk factor associated with reoperation, and re-operation also seems to be more likely with a greater extent of preoperative disease.[13,14]. Other studies have shown that factors such as smoking, the presence of granulomas and perianal disease are predictors of disease recurrence [15-17].
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