The risk of developing pouchitis is much higher in patients with pre-operative extra-intestinal manifestations  and primary sclerosing cholangitis . More controversial is the predictive role of anti-neu-trophil cytoplasmic antibody with a perinuclear pattern (p-ANCA) [10-15] and of the pre-operative extent of UC [16-17]. Similarly to UC, smoking may be protective against the development of pouchitis (Table 1) . The surgical technique (different type of reservoir) does not influence the frequency of pouchitis [19-20].
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