Prevention of Post Operative Relapse

The 5-aminosalicylates remain the most controversial agents in the maintenance of remission of Crohn's disease. Several studies and a recent meta-analysis have shown no significant benefit in comparison to placebo, but the meta-analysis suggested a potential role in patients with surgically induced remission, where mesalazine lowered the risk of relapse by 13% [26]. These general data were better clarified in a randomised study in which 5-ASA gained a significant reduction in relapse rate in postoperative prophylaxis in a subgroup of patients with limited ileal disease [27]. Therefore, while waiting for confirmation data, our team routinely treats resected patients for ileal CD.

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