Other Drugs

A very small number or anecdotic cases are treated with other drugs sometimes in combination with NSAIDs or SERMs: warfarin and vitamin K [98], interferon-a-2b, progesterone, prednisolone, ascorbic acid, testosterone, analogues of LHRH, and pir-fenidone [99-102]. Recently, imatinib mesylate has been shown to be active in two patients not affected by FAP with extra-abdominal DT refractory to other medical treatments. Interestingly, positivity for c-kit as well as PDGFR-a and PGDFR-P was found at immunohistochemical and qualitative RT-PCR analysis [103]. These data must be confirmed on DTs in association with FAP and on a larger series.

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