A number of novel therapies have been suggested for the treatment of fistulizing CD. The use of fibrin glue and plasma factor XIII concentrates have been advanced as adjunctive therapies in the management of perianal fistulae. Hyperbaric oxygen has also been suggested as an adjunctive therapy in healing fistulizing CD. Although case reports have documented successful healing during therapy, no randomized placebo-controlled studies have been performed to confirm these findings. Further studies are necessary to assess the role of these therapies in the management of fistulizing CD .
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