Half a century ago, in the late 1950s, some neurosurgeons reported on the treatment of patients with ulcerative colitis and psychosis with a prefrontal lobotomy followed by an improvement of their abdominal symptoms . As a few patients had profound psychological disturbances due to the unde-sired damage of cerebral pathways, some years later the technique was refined using a more selective elec-trocautery approach aimed at dividing part of the association fibres between the frontal cortex and the thalamic-hypothalamic system, with better results . However, whether these results were due to a spontaneous remission or to the intervention remained unclear, so the procedure was abandoned.
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