Mycophenolate mofetil

Mycophenolate mofetil (MFF) is a potent immuno-suppressant that inhibits lymphocyte proliferation through a blockade of guanosine nucleotide synthesis. In a study comparing the efficacy of AZA plus steroids vs. MMF plus steroids, MMF produced a more rapid improvement in the activity index in cases with severe activity and a similar response in cases with moderate activity [52].

Uncontrolled case series have suggested the efficacy of mycophenolate in long-term maintenance of remission [53-56]. Wenzl et al. [56] observed that almost 55% of patients with complicated CD responded, but 64% of the initial responders relapsed within 18 months. Well-designed placebo-controlled trials are necessary to establish the role of this drug.

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