Conflicting results are available on the efficacy of MTX in UC. In an early RCT, no significant differences were found between oral MTX (12.5 mg/week) and placebo at 9 months in 67 UC patients . In another RCT, MTX (15 mg/week) was as effective as 6-MP (1.5 mg/kg/day) and 5-ASA (3 g/day), but less effective in maintaining remission in steroid-dependent UC patients. A dose of subcutaneous MTX at 15 and 25 mg/week showed a similar efficacy in inducing remission .
It is often accepted that MTX is more effective in Crohn's disease than in UC. However, in a recent retrospective study on 22 UC and 48 CD patients treated with MTX (orally or i.m.) with a mean maintenance dose of 20 mg/week, remission was achieved in 34 of 55 patients who completed more than 3 months of treatment. Treatment was equally effective for Crohn's disease and UC. Life-table analysis showed that the chances of remaining in remission at 12, 24 and 36 months of treatment were 90, 73 and 51%, respectively .
Was this article helpful?
Moles, warts, and other unsightly irregularities of the skin can be bothersome and even embarrassing. They can be removed naturally... Removing Warts and Moles Naturally! If you have moles, warts, and other skin irregularities that you cannot cover up affecting the way you look, you can have them removed. Doctors can be extremely expensive. Learn the natural ways you can remove these irregularities in the comfort of your own home.