Immunomodulatory therapy with interferon-beta (IFN-P) might represent a new strategy in UC due to the divergent effects of this cytokine on the immuno-logical and inflammatory process. IFN-P produces an anti-inflammatory effect by inhibiting the production of IFN-y and TNF-a and by antagonising early events in the IFN-y signalling pathway. In addition, IFN-P increases the expression of anti-inflammatory cytokine IL-10 and enhances T suppressor and NK cell activity.
A pilot-study investigated whether IFN-P could induce clinical remission in 25 patients with steroid-refractory UC. Patients were treated with 0.5 MIU human IFN-P i.v. (n=18) or 1MIU recombinant IFN-
P s.c. (n=7). Maintenance treatment was carried out for 52±78.8 weeks, 3 times a week. Twenty-two patients entered remission with a mean time to response of 3 weeks and a mean duration of remission of 13 weeks . However, in two subsequent larger trials, no differences were observed between IFN-P and placebo [71-72].
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Everything you wanted to know about. How To Cure Tennis Elbow. Are you an athlete who suffers from tennis elbow? Contrary to popular opinion, most people who suffer from tennis elbow do not even play tennis. They get this condition, which is a torn tendon in the elbow, from the strain of using the same motions with the arm, repeatedly. If you have tennis elbow, you understand how the pain can disrupt your day.