Hw to Prevent the Carcinogenic Progression b Chemical Aentsthe Chemoprevention

Cancer chemoprevention, as first defined by Sporn in 1976 [2], uses natural, synthetic, or biological chemical agents to reverse, suppress, or prevent carcinogenic progression. It is based on the concepts of mul-tifocal field carcinogenesis and multistep carcino-genesis. In field carcinogenesis, diffuse epithelial injury in tissues such as the aerodigestive tract, results from generalised carcinogen exposure throughout the field and clonal proliferation of mutated cells. Genetic changes exist throughout the field and increase the likelihood that one or more premalignant and malignant lesions may develop within that field. Multistep carcinogenesis describes a stepwise accumulation of alterations, both geno-typic and phenotypic. Arresting one or several of the steps may impede or delay the development of cancer. This has been described particularly well in studies involving precancerous and cancerous lesions of the head and neck, which focus on oral premalignant lesions (leukoplakia and erythroplakia) and their associated increased risk of progression to cancer. In addition to histologic assessment, intermediate markers of response are needed to assess the validity of these therapies in a timely and cost-efficient manner.

Was this article helpful?

0 0
10 Ways To Fight Off Cancer

10 Ways To Fight Off Cancer

Learning About 10 Ways Fight Off Cancer Can Have Amazing Benefits For Your Life The Best Tips On How To Keep This Killer At Bay Discovering that you or a loved one has cancer can be utterly terrifying. All the same, once you comprehend the causes of cancer and learn how to reverse those causes, you or your loved one may have more than a fighting chance of beating out cancer.

Get My Free Ebook

Post a comment