Hereditary Mixed Polyposis Syndrome

This is an autosomal dominant disorder that has been mapped to chromosome 6q. Five types of polyps have been described in individuals with this disorder:

• tubular adenomas

• Villous adenomas

• Flat adenomas

• Hyperplastic polyps

• Typical juvenile polyps.

Colorectal cancer is also seen in this disorder, which might be a variant of JP. But in JP, adenomas are uncommon (2%) while in hereditary mixed polypo-sis, the number of polyps are fewer than seen in JP [19]. JP usually presents one decade earlier than hereditary mixed polyposis.

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