Glucocorticoids have anti-inflammatory, anti-effusive, and anti-allergic properties. They decrease the effects of early inflammation including mediator release and leukocyte migration and later fibroblast activation. They also decrease histamine release .
Prednisone, prednisolone and methylpred-nisolone are most frequently used orally for 3-6 weeks for exacerbations of mild and moderate CD, and then the dose is decreased for 2-3 months. Severe cases of the disease require intravenous steroids application with hydrocortisone or methyl-prednisolone being the most frequently used. An NCCDS study showed that prednisone treatment in a dose of 0.25-0.75 mg/kg/day was effective in 60% of patients compared to 20% in a placebo group . Eighty-two percent effectiveness of methylpred-nisolone in a dose of 48 mg/kg in severe cases and 8 mg/kg in maintenance treatment was described in the European study ECCDS. It confirmed glucocorti-coid induced remission of the active CD from 60 to 80% . In patients with pathological changes located in ileal and ileocecal regions, oral budesonide at a dose of 9 mg/day is recommended. Comparative studies of 9 mg/day of budesonide and 40 mg/day of prednisolone showed similar effectiveness of both drugs at 53 and 66% respectively, with fewer side effects from budesonide . Thomson's comparative study of 2x2 g/day of mesalazine and 9 g/day of budesonide in mild and moderate CD, showed higher effectiveness of budesonide in decreasing symptoms of the active disease along with improved quality of life in that group . With a steroid treatment, approximately 20-36% of patients develop steroid dependency and thus require constant steroid dosage while approximately 20% develop steroid resistance.
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Everything you wanted to know about. How To Cure Tennis Elbow. Are you an athlete who suffers from tennis elbow? Contrary to popular opinion, most people who suffer from tennis elbow do not even play tennis. They get this condition, which is a torn tendon in the elbow, from the strain of using the same motions with the arm, repeatedly. If you have tennis elbow, you understand how the pain can disrupt your day.