Many study groups have focused on gadolinium-enhanced Tl-weighted images for assessment of disease [27-30], as both localization and severity of inflammation can be appraised with this sequence. Inflamed bowel segments show pathological enhancement after administration of intravenous gadolinium. When combining Tl-weighted sequences with fat suppression and use of intravenous gadolin-ium-chelates, very good differentiation in contrast is obtained between the pathologically enhancing bowel wall and the dark bowel lumen and suppressed perivisceral fat (Fig. 2). The marked increase in signal intensity of inflamed bowel after administration of a ■ b
Fig. 2. Coronal fat suppressed Tl-weighted spoiled gradient echo sequence acquired before (a) and 30 s following intravenous administration of gadolinium chelate (b), demonstrating marked parietal enhancement of the distal ileal loop (arrow)
intravenous gadolinium is due to increased tissue perfusion and vascular permeability (Fig. 2).
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