Functional disorders of the small bowel that may lead to intestinal failure include disorders of motility and disorders of enterocyte function. The most common motility disorders are chronic pseudo-obstruction, visceral myopathy, visceral neuropathy, total intestinal aganglionosis, and some forms of mitochondri-al respiratory chain disorders that affect gastrointestinal motor function.
Epithelial disorders causing intractable secretory diarrhea or failure of absorption are more common in children and include microvillus inclusion disease, tufting enteropathy and autoimmune enteritis.
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