This syndrome includes generalized GI polyposis in association with neuroectodermal changes consisting of alopecia, hyperpigmentation and nail atrophy. Electron microscopic studies of the skin reveal increased numbers of melanin granules in kerato-cytes, increased number of melanosomes in melanocytes, increased melanocytes, compact hyper-keratosis, perivascular inflammation and exocytosis. A number of haematologic, neurologic and metabolic abnormalities are associated with Cronkhite-Cana-da syndrome.
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