Corticosteroids are potent anti-inflammatory agents for moderate to severe relapses of both UC and CD. They have no role in maintenance therapy for either disease. They act through inhibition of several inflammatory pathways via the suppression of inter-leukin transcription, induction of IkB (an inhibitor of the NFkB complex), suppression of the arachidon-ic acid metabolism and stimulation of apoptosis of lymphocytes within the lamina propria of the gut. Many strategies attempt to maximise their topical effects, while limiting systemic side effects. As for example, budesonide is a poorly absorbed corticos-teroid with limited bioavailability and extensive firstpass metabolism which reduces its systemic toxicity in ileocecal CD or UC.
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Everything you wanted to know about. How To Cure Tennis Elbow. Are you an athlete who suffers from tennis elbow? Contrary to popular opinion, most people who suffer from tennis elbow do not even play tennis. They get this condition, which is a torn tendon in the elbow, from the strain of using the same motions with the arm, repeatedly. If you have tennis elbow, you understand how the pain can disrupt your day.