In conclusion, patients with UC who undergo an ileal anal pouch operation also require surveillance. More recent research has focused on the chemoprevention of CRC in IBD using aminosalicylate (5-ASA) preparations. Several retrospective correlative studies have suggested that the long-term use of 5-ASA in IBD patients may significantly reduce the risk of development of CRC. Moody et al. [54] demonstrated that patients with UC who did not comply with 5-ASA therapies were significantly more likely to develop CRC than their counterparts. Eaden et al. [55] found that regular 5-ASA therapy reduces cancer risk by 75% in IBD patients. Mesalazine at a dose of 1.2 g/day or greater reduced CRC risk by 91% compared to no treatment and was also supportive when taken at lower doses. They concluded that the benefit of regular consumption of 5-ASA was equal to frequent visits to a hospital physician.

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