Conclusion

In conclusion, patients with UC who undergo an ileal anal pouch operation also require surveillance. More recent research has focused on the chemoprevention of CRC in IBD using aminosalicylate (5-ASA) preparations. Several retrospective correlative studies have suggested that the long-term use of 5-ASA in IBD patients may significantly reduce the risk of development of CRC. Moody et al. [54] demonstrated that patients with UC who did not comply with 5-ASA therapies were significantly more likely to develop CRC than their counterparts. Eaden et al. [55] found that regular 5-ASA therapy reduces cancer risk by 75% in IBD patients. Mesalazine at a dose of 1.2 g/day or greater reduced CRC risk by 91% compared to no treatment and was also supportive when taken at lower doses. They concluded that the benefit of regular consumption of 5-ASA was equal to frequent visits to a hospital physician.

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